A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus.

Voisset, Cécile; Daskalogianni, Chrysoula; Contesse, Marie-Astrid; Mazars, Anne; Arbach, Hratch; Le Cann, Marie; Soubigou, Flavie; Apcher, Sébastien; Fåhraeus, Robin; Blondel, Marc

Voisset, Cécile; Daskalogianni, Chrysoula; Contesse, Marie-Astrid; Mazars, Anne; Arbach, Hratch; Le Cann, Marie; Soubigou, Flavie; Apcher, Sébastien; Fåhraeus, Robin; Blondel, Marc.

Affiliation

Voisset C; Institut National de la Santé et de la Recherche Médicale UMR 1078; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé; Etablissement Français du Sang (EFS) Bretagne; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest F-29200, France.

Dis Model Mech ; 7(4): 435-44, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24558096

Subject(s)

Antiviral Agents/pharmacology; Biological Assay/methods; Herpesvirus 4, Human/drug effects; Herpesvirus 4, Human/immunology; Immune Evasion/drug effects; Saccharomyces cerevisiae/metabolism; Antigen Presentation/drug effects; Antiviral Agents/analysis; Antiviral Agents/chemistry; DNA Damage; Doxorubicin/chemistry; Doxorubicin/pharmacology; Drug Evaluation, Preclinical; Epstein-Barr Virus Nuclear Antigens/chemistry; Epstein-Barr Virus Nuclear Antigens/metabolism; HEK293 Cells; Humans; Protein Biosynthesis/drug effects; Protein Structure, Tertiary; T-Lymphocytes/drug effects; T-Lymphocytes/immunology

Key words

5-fluorouracil; Cell-based drug screening; Daunorubicin; Doxorubicin; EBNA1 GAr domain; EBV-associated cancers; Immune evasion; Yeast-based models

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Saccharomyces cerevisiae / Biological Assay / Herpesvirus 4, Human / Immune Evasion Language: En Journal: Dis Model Mech Year: 2014 Type: Article Affiliation country: France

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