Novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation.
Molecules
; 19(2): 2469-80, 2014 Feb 21.
Article
in En
| MEDLINE
| ID: mdl-24566315
ABSTRACT
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Full text:
1
Database:
MEDLINE
Main subject:
Phenanthridines
/
Amaryllidaceae Alkaloids
/
Antineoplastic Agents
Language:
En
Journal:
Molecules
Year:
2014
Type:
Article
Affiliation country:
China