4ß-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys.

Li, Ke; Zhao, Sylvia; Zhang, Lingling; Wu, Xiaoyun; Shu, Pan; Wang, Yang; Feng, Hao; Gu, Zheming; Han Hsu, Helen

Li, Ke; Zhao, Sylvia; Zhang, Lingling; Wu, Xiaoyun; Shu, Pan; Wang, Yang; Feng, Hao; Gu, Zheming; Han Hsu, Helen.

Affiliation

Li K; Drug Safety Sciences Asia Pacific, Janssen Research & Development, Shanghai, China (K.L., S.Z., X.W., Y.W., H.H.H.) and XBL-China, Nanjing, China (L.Z., P.S., H.F., Z.G.).

Drug Metab Dispos ; 42(5): 839-43, 2014 May.

Article in En | MEDLINE | ID: mdl-24595680

Subject(s)

Cytochrome P-450 CYP3A/metabolism; Hydroxycholesterols/blood; Administration, Oral; Animals; Biomarkers/blood; Biotransformation; Cholesterol/metabolism; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A/biosynthesis; Cytochrome P-450 CYP3A/genetics; Drug Evaluation, Preclinical; Enzyme Induction; Female; Macaca fascicularis; Male; Midazolam/blood; Midazolam/pharmacokinetics; Rifampin/pharmacology; Substrate Specificity; Tandem Mass Spectrometry

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Full text: 1 Database: MEDLINE Main subject: Cytochrome P-450 CYP3A / Hydroxycholesterols Type of study: Prognostic_studies Language: En Journal: Drug Metab Dispos Year: 2014 Type: Article

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