Physiological and biochemical analysis to reveal the molecular basis for black widow spiderling toxicity.

Peng, Xiaozhen; Zhang, Yiya; Liu, Jinyan; Yu, Hai; Chen, Jia; Lei, Qian; Wang, Xianchun; Liang, Songping

Peng, Xiaozhen; Zhang, Yiya; Liu, Jinyan; Yu, Hai; Chen, Jia; Lei, Qian; Wang, Xianchun; Liang, Songping.

Affiliation

Peng X; Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China.

J Biochem Mol Toxicol ; 28(5): 198-205, 2014 May.

Article in En | MEDLINE | ID: mdl-24616210

Subject(s)

Black Widow Spider; Neurotoxins/toxicity; Tissue Extracts/toxicity; Animals; Black Widow Spider/chemistry; Black Widow Spider/growth & development; Black Widow Spider/physiology; Diaphragm/drug effects; Diaphragm/innervation; Electrophoresis, Polyacrylamide Gel; Female; Ganglia, Spinal/drug effects; Ganglia, Spinal/metabolism; In Vitro Techniques; Ion Channels/antagonists & inhibitors; Lethal Dose 50; Male; Mice, Inbred Strains; Neuromuscular Junction/drug effects; Neuromuscular Junction/physiology; Neurons/drug effects; Neurons/metabolism; Neurotoxins/isolation & purification; Periplaneta; Synaptic Transmission/drug effects; Tissue Extracts/isolation & purification

Key words

Black Widow Spider; Characterization; Extract; Newborn Spiderling; Toxicity

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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Tissue Extracts / Black Widow Spider / Neurotoxins Language: En Journal: J Biochem Mol Toxicol Year: 2014 Type: Article

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