Inhibition of AMPK/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells.

Lu, Can; Wang, Wenwen; Jia, Yongsheng; Liu, Xiaodong; Tong, Zhongsheng; Li, Binghui

Lu, Can; Wang, Wenwen; Jia, Yongsheng; Liu, Xiaodong; Tong, Zhongsheng; Li, Binghui.

Affiliation

Lu C; Laboratory of Cancer Cell Biology, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, P.R. China; Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, P.R. China.

J Cell Biochem ; 115(8): 1458-66, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24619908

Subject(s)

AMP-Activated Protein Kinases/genetics; Apoptosis/genetics; Breast Neoplasms/genetics; Sesquiterpenes/administration & dosage; AMP-Activated Protein Kinases/antagonists & inhibitors; Apoptosis/drug effects; Autophagy/drug effects; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Cell Cycle Checkpoints/drug effects; Female; Humans; MCF-7 Cells; Reactive Oxygen Species/metabolism

Key words

AMPK; APOPTOSIS; AUTOPHAGY; PARTHENOLIDE; ROS

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Full text: 1 Database: MEDLINE Main subject: Sesquiterpenes / Breast Neoplasms / Apoptosis / AMP-Activated Protein Kinases Language: En Journal: J Cell Biochem Year: 2014 Type: Article

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