Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann-Pick disease type C1 mice.

Williams, Ian M; Wallom, Kerri-Lee; Smith, David A; Al Eisa, Nada; Smith, Claire; Platt, Frances M

Williams, Ian M; Wallom, Kerri-Lee; Smith, David A; Al Eisa, Nada; Smith, Claire; Platt, Frances M.

Affiliation

Williams IM; Dept. of Pharmacology, University of Oxford, UK. Electronic address: ian.williams@pharm.ox.ac.uk.
Wallom KL; Dept. of Pharmacology, University of Oxford, UK.
Smith DA; Dept. of Pharmacology, University of Oxford, UK.
Al Eisa N; Dept. of Pharmacology, University of Oxford, UK.
Smith C; Dept. of Pharmacology, University of Oxford, UK.
Platt FM; Dept. of Pharmacology, University of Oxford, UK. Electronic address: frances.platt@pharm.ox.ac.uk.

Neurobiol Dis ; 67: 9-17, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24631719

Subject(s)

1-Deoxynojirimycin/analogs & derivatives; Curcumin/therapeutic use; Ibuprofen/therapeutic use; Neuroprotective Agents/therapeutic use; Niemann-Pick Disease, Type C/drug therapy; 1-Deoxynojirimycin/therapeutic use; Animals; Cerebellum/drug effects; Cerebellum/pathology; Drug Therapy, Combination; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Niemann-Pick C1 Protein; Proteins/genetics

Key words

Cerebellum; Combination therapy; Curcumin; Ibuprofen; Miglustat; Neuroprotection; NiemannPick disease type C1

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Ibuprofen / 1-Deoxynojirimycin / Neuroprotective Agents / Curcumin / Niemann-Pick Disease, Type C Language: En Journal: Neurobiol Dis Year: 2014 Type: Article

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