Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice.

Terse, Pramod; Engelke, Kory; Chan, Kenneth; Ling, Yonghua; Sharpnack, Douglas; Saunthararajah, Yogen; Covey, Joseph M

Terse, Pramod; Engelke, Kory; Chan, Kenneth; Ling, Yonghua; Sharpnack, Douglas; Saunthararajah, Yogen; Covey, Joseph M.

Affiliation

Terse P; Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, Bethesda, MD, USA. Email: tersep@mail.nih.gov.

Int J Toxicol ; 33(2): 75-85, 2014.

Article in En | MEDLINE | ID: mdl-24639139

Subject(s)

Antimetabolites/toxicity; Azacitidine/analogs & derivatives; Tetrahydrouridine/toxicity; Animals; Antimetabolites, Antineoplastic; Azacitidine/toxicity; Blood Cell Count; Body Weight/drug effects; Bone Marrow Cells/drug effects; Decitabine; Eating/drug effects; Female; Male; Mice; Micronucleus Tests; Pharmacokinetics

Key words

CD-1 mice; combination therapy; decitabine; hematopoietic tissue; lymphoid tissue; tetrahydrouridine

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Full text: 1 Database: MEDLINE Main subject: Azacitidine / Tetrahydrouridine / Antimetabolites Language: En Journal: Int J Toxicol Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Azacitidine / Tetrahydrouridine / Antimetabolites Language: En Journal: Int J Toxicol Year: 2014 Type: Article