Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-&#954;B signaling pathway in experimental traumatic brain injury.

Zhu, Hai-tao; Bian, Chen; Yuan, Ji-chao; Chu, Wei-hua; Xiang, Xin; Chen, Fei; Wang, Cheng-shi; Feng, Hua; Lin, Jiang-Kai

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury.

Zhu, Hai-tao; Bian, Chen; Yuan, Ji-chao; Chu, Wei-hua; Xiang, Xin; Chen, Fei; Wang, Cheng-shi; Feng, Hua; Lin, Jiang-Kai.

Affiliation

Lin JK; Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China. jklin@tmmu.edu.cn.

J Neuroinflammation ; 11: 59, 2014 Mar 27.

Article in En | MEDLINE | ID: mdl-24669820

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Curcumin/pharmacology; Curcumin/therapeutic use; Down-Regulation/drug effects; Encephalitis/drug therapy; Signal Transduction/drug effects; Toll-Like Receptor 4/metabolism; Animals; Brain Edema/diagnosis; Brain Edema/etiology; Brain Injuries/complications; Brain Injuries/genetics; Cells, Cultured; Cerebral Cortex/cytology; Coculture Techniques; Disease Models, Animal; Down-Regulation/genetics; Embryo, Mammalian; Encephalitis/etiology; Encephalitis/genetics; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Differentiation Factor 88/metabolism; Signal Transduction/genetics; Time Factors; Toll-Like Receptor 4/genetics

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Signal Transduction / Down-Regulation / Anti-Inflammatory Agents, Non-Steroidal / Curcumin / Encephalitis / Toll-Like Receptor 4 Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Language: En Journal: J Neuroinflammation Year: 2014 Type: Article

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