Determination of swertianolin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.

He, Jun; Tian, Chengwang; Ouyang, Huizi; Adelakun, Tiwalade A; Yu, Bin; Chang, Yanxu; Pan, Guixiang; Jiang, Linghuo; Gao, Xiumei

He, Jun; Tian, Chengwang; Ouyang, Huizi; Adelakun, Tiwalade A; Yu, Bin; Chang, Yanxu; Pan, Guixiang; Jiang, Linghuo; Gao, Xiumei.

Affiliation

He J; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

Biomed Chromatogr ; 28(10): 1418-22, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24687287

Subject(s)

Chromatography, Liquid/methods; Glucosides/blood; Swertia/chemistry; Tandem Mass Spectrometry/methods; Xanthones/blood; Administration, Oral; Animals; Glucosides/chemistry; Glucosides/pharmacokinetics; Linear Models; Liquid-Liquid Extraction/methods; Male; Plant Extracts/administration & dosage; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rutin; Xanthones/chemistry; Xanthones/pharmacokinetics

Key words

LC-MS/MS; pharmacokinetics; swertianolin

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Full text: 1 Database: MEDLINE Main subject: Chromatography, Liquid / Swertia / Xanthones / Tandem Mass Spectrometry / Glucosides Type of study: Prognostic_studies Language: En Journal: Biomed Chromatogr Year: 2014 Type: Article Affiliation country: China

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