Histological and ultrastructural studies on the toxic effect of pan masala and its amelioration by Elettaria cardamomum.
Chin J Nat Med
; 12(3): 199-203, 2014 Mar.
Article
in En
| MEDLINE
| ID: mdl-24702806
ABSTRACT
AIM:
To investigate the histological and ultrastructural changes observed in pan masala intoxicated mammalian testes under the effect of cardamom.METHODS:
Male Swiss mice were given pan masala orally at a dose of 2% of the feed and cardamom at a dose of 0.2% of the feed. They were divided into three groups, control (Group I), pan masala-treated (Group II), and a combination of pan masala and cardamom-treated group (Group III). Histologically, the testes of Group II mice displayed degeneration of tubular epithelium, disruption of spermatogenesis, and a marked reduction in germ cells.RESULTS:
When cardamom was given, damage was less with fewer distorted cells and also improvement with normal tubules and spermatid differentiation in Group III. Ultrastructurally, pan masala-treated testes showed cytoplasmic vacuolation, shrinkage and pyknotic nuclei of spermatogonia, and abnormal acrosomal granules.CONCLUSION:
When cardamom was given, the amelioration process was more evident showing a comparable morphology with control.Key words
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Aromoterapia
Main subject:
Areca
/
Spermatogenesis
/
Spermatozoa
/
Testicular Diseases
/
Testis
/
Tobacco, Smokeless
/
Elettaria
Language:
En
Journal:
Chin J Nat Med
Year:
2014
Type:
Article