Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs.
Eur J Drug Metab Pharmacokinet
; 40(2): 219-24, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-24719213
ABSTRACT
The present study was conducted to investigate the effects of some commonly used herbs namely Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on the pharmacokinetics of sildenafil in beagle dogs. The study design involved four treatments in a non-balanced crossover design. Sildenafil was given one tablet 100 mg orally to each dog and blood samples were obtained. After a suitable washout period, animals were commenced on a specific herb treatment for 1 week. Blood samples were withdrawn at different time intervals and sildenafil was analyzed by HPLC method. Oral administration of Nigella sativa resulted in reduction of AUC0-∞, C max and t 1/2 as compared to the control. Treatment of Lepidium sativum resulted in a significant reduction in the C max and AUC. There were no significant differences between the rests of the pharmacokinetic parameters relative to those of the control. For Trigonella foenum-graecum, the effects were similar to those obtained in case of Lepidium sativum. It was concluded that concurrent use of investigated herbs alters the pharmacokinetics of sildenafil. Co-administration of investigated herbs should be cautious since their concomitant use might result in decrease in sildenafil bioavailability.
Full text:
1
Database:
MEDLINE
Main subject:
Piperazines
/
Sulfonamides
/
Nigella sativa
/
Trigonella
/
Lepidium sativum
/
Herb-Drug Interactions
Type of study:
Prognostic_studies
Language:
En
Journal:
Eur J Drug Metab Pharmacokinet
Year:
2015
Type:
Article
Affiliation country:
Saudi Arabia