Amplification of aminoglycoside resistance gene aphA1 in Acinetobacter baumannii results in tobramycin therapy failure.

McGann, Patrick; Courvalin, Patrice; Snesrud, Erik; Clifford, Robert J; Yoon, Eun-Jeong; Onmus-Leone, Fatma; Ong, Ana C; Kwak, Yoon I; Grillot-Courvalin, Catherine; Lesho, Emil; Waterman, Paige E

McGann, Patrick; Courvalin, Patrice; Snesrud, Erik; Clifford, Robert J; Yoon, Eun-Jeong; Onmus-Leone, Fatma; Ong, Ana C; Kwak, Yoon I; Grillot-Courvalin, Catherine; Lesho, Emil; Waterman, Paige E.

mBio ; 5(2): e00915, 2014 Apr 22.

Article in En | MEDLINE | ID: mdl-24757213

Subject(s)

Acid Phosphatase/genetics; Acinetobacter Infections/drug therapy; Acinetobacter baumannii/enzymology; Anti-Bacterial Agents/therapeutic use; Drug Resistance, Bacterial; Gene Amplification; Tobramycin/therapeutic use; Acid Phosphatase/metabolism; Acinetobacter Infections/microbiology; Acinetobacter baumannii/drug effects; Acinetobacter baumannii/genetics; Acinetobacter baumannii/isolation & purification; DNA Transposable Elements; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; Gene Dosage; Genome, Bacterial; Humans; Male; Microbial Sensitivity Tests; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Treatment Failure; Young Adult

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Tobramycin / Acid Phosphatase / Acinetobacter Infections / Gene Amplification / Drug Resistance, Bacterial / Acinetobacter baumannii / Anti-Bacterial Agents Type of study: Prognostic_studies Language: En Journal: MBio Year: 2014 Type: Article

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