Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity.

Carlsten, Chris; MacNutt, Meaghan J; Zhang, Zhihong; Sava, Francesco; Pui, Mandy M

Carlsten, Chris; MacNutt, Meaghan J; Zhang, Zhihong; Sava, Francesco; Pui, Mandy M.

Affiliation

Carlsten C; Department of Medicine, Respiratory Division.

Toxicol Sci ; 139(2): 479-87, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24814479

Subject(s)

Acetylcysteine/therapeutic use; Antioxidants/therapeutic use; Respiratory Hypersensitivity/chemically induced; Respiratory Hypersensitivity/prevention & control; Vehicle Emissions/toxicity; Acetylcysteine/administration & dosage; Adult; Antioxidants/administration & dosage; Bronchoconstrictor Agents/pharmacology; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Methacholine Chloride/pharmacology; Middle Aged; Respiratory Function Tests; Young Adult

Key words

air pollution; airway responsiveness; anti-oxidant; asthma; diesel exhaust

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Full text: 1 Database: MEDLINE Main subject: Acetylcysteine / Respiratory Hypersensitivity / Vehicle Emissions / Antioxidants Type of study: Clinical_trials Language: En Journal: Toxicol Sci Year: 2014 Type: Article

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