Genotoxicity testing of peptides: folate deprivation as a marker of exaggerated pharmacology.

Guérard, Melanie; Zeller, Andreas; Festag, Matthias; Schubert, Christine; Singer, Thomas; Müller, Lutz

Guérard, Melanie; Zeller, Andreas; Festag, Matthias; Schubert, Christine; Singer, Thomas; Müller, Lutz.

Affiliation

Guérard M; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland. Electronic address: melanie.guerard@roche.com.
Zeller A; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland.
Festag M; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland.
Schubert C; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland.
Singer T; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland.
Müller L; F. Hoffmann-La Roche Ltd., Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 183, 4070 Basel, Switzerland.

Toxicol Appl Pharmacol ; 279(3): 419-427, 2014 Sep 15.

Article in En | MEDLINE | ID: mdl-24997324

Subject(s)

Folic Acid Deficiency/chemically induced; Mutagenicity Tests/methods; Mutagens; Peptides/toxicity; Animals; Body Temperature/drug effects; Bone Marrow Cells/drug effects; Bone Marrow Cells/ultrastructure; Cell Line, Tumor; Chromosome Aberrations/drug effects; Eating/drug effects; Erythropoiesis/drug effects; Folic Acid Deficiency/genetics; Humans; Lymphocytes/drug effects; Lymphocytes/ultrastructure; Malnutrition/chemically induced; Mice; Mice, Knockout; Micronucleus Tests; Rats; Receptors, Gastrointestinal Hormone/metabolism; Salmonella typhimurium/drug effects; Salmonella typhimurium/genetics

Key words

Folate; Integration; Micronuclei; Peptide

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Full text: 1 Database: MEDLINE Main subject: Peptides / Folic Acid Deficiency / Mutagenicity Tests / Mutagens Language: En Journal: Toxicol Appl Pharmacol Year: 2014 Type: Article

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