Syzygium aromaticum L. (Clove) extract regulates energy metabolism in myocytes.
J Med Food
; 17(9): 1003-10, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-24999964
ABSTRACT
The prevalence of metabolic syndrome and type 2 diabetes is increasing worldwide. Herbs and spices have been used for the treatment of diabetes for centuries in folk medicine. Syzygium aromaticum L. (Clove) extracts (SE) have been shown to perform comparably to insulin by significantly reducing blood glucose levels in animal models; however, the mechanisms are not well understood. We investigated the effects of clove on metabolism in C2C12 myocytes and demonstrated that SE significantly increases glucose consumption. The phosphorylation of AMP-activated protein kinase (AMPK), as well as its substrate, acetyl-CoA carboxylase (ACC) was increased by SE treatment. SE also transcriptionally regulates genes involved in metabolism, including sirtuin 1 (SIRT1) and PPARγ coactivator 1α (PGC1α). Nicotinamide, an SIRT1 inhibitor, diminished SE's effects on glucose consumption. Furthermore, treatment with SE dose-dependently increases muscle glycolysis and mitochondrial spare respiratory capacity. Overall, our study suggests that SE has the potential to increase muscle glycolysis and mitochondria function by activating both AMPK and SIRT1 pathways.
Key words
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Main subject:
Plant Extracts
/
Syzygium
/
Energy Metabolism
/
Glucose
/
Glycolysis
/
Mitochondria
/
Muscles
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
J Med Food
Year:
2014
Type:
Article
Affiliation country:
United States