Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.

Zhang, Yi-Wen; Bao, Mei-Hua; Wang, Guo; Qu, Qiang; Zhou, Hong-Hao

Zhang, Yi-Wen; Bao, Mei-Hua; Wang, Guo; Qu, Qiang; Zhou, Hong-Hao.

Pharmazie ; 69(7): 532-6, 2014 Jul.

Article in En | MEDLINE | ID: mdl-25073399

Subject(s)

Alkaloids/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Cholinesterase Inhibitors/pharmacology; Cytochrome P-450 CYP3A/biosynthesis; Diterpenes, Kaurane/pharmacology; Pyrazines/pharmacology; Receptors, Steroid/drug effects; Sesquiterpenes/pharmacology; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Enzyme Induction/drug effects; Genes, Reporter/genetics; Humans; Plasmids/genetics; Pregnane X Receptor; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Signal Transduction/drug effects; Transfection

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Database: MEDLINE Main subject: Pyrazines / Sesquiterpenes / Receptors, Steroid / Cholinesterase Inhibitors / Diterpenes, Kaurane / Alkaloids / Cytochrome P-450 CYP3A / Antineoplastic Agents, Phytogenic Language: En Journal: Pharmazie Year: 2014 Type: Article

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