Tween-80 and impurity induce anaphylactoid reaction in zebrafish.

Yang, Rui; Lao, Qiao-Cong; Yu, Hang-Ping; Zhang, Yong; Liu, Hong-Cui; Luan, Lin; Sun, Hui-Min; Li, Chun-Qi

Yang, Rui; Lao, Qiao-Cong; Yu, Hang-Ping; Zhang, Yong; Liu, Hong-Cui; Luan, Lin; Sun, Hui-Min; Li, Chun-Qi.

Affiliation

Yang R; National Institutes for Food and Drug Control, China Food and Drug Administration (CFDA), No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050, China.

J Appl Toxicol ; 35(3): 295-301, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25345596

Subject(s)

Anaphylaxis/chemically induced; Drug Contamination; Excipients/toxicity; Polysorbates/toxicity; Zebrafish/immunology; Anaphylaxis/enzymology; Anaphylaxis/immunology; Animals; Drugs, Chinese Herbal/administration & dosage; Ethylene Chlorohydrin/chemistry; Ethylene Chlorohydrin/toxicity; Ethylene Glycol/chemistry; Ethylene Glycol/toxicity; Excipients/chemistry; High-Throughput Screening Assays; Hydrogen Peroxide/chemistry; Hydrogen Peroxide/toxicity; Intestines/drug effects; Mast Cells/drug effects; Polysorbates/chemistry; Tryptases/metabolism

Key words

Tween-80; anaphylactoid reaction; impurity; tryptase; zebrafish

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Polysorbates / Zebrafish / Drug Contamination / Excipients / Anaphylaxis Type of study: Prognostic_studies Language: En Journal: J Appl Toxicol Year: 2015 Type: Article Affiliation country: China

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