Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans.
Food Funct
; 6(1): 204-10, 2015 Jan.
Article
in En
| MEDLINE
| ID: mdl-25347552
ABSTRACT
Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.
Full text:
1
Database:
MEDLINE
Main subject:
Appetite Regulation
/
Plant Oils
/
Energy Intake
/
Oleic Acids
/
Oleic Acid
/
Endocannabinoids
/
Breakfast
Type of study:
Clinical_trials
Country/Region as subject:
Europa
Language:
En
Journal:
Food Funct
Year:
2015
Type:
Article
Affiliation country:
Italy