Nymphayol increases glucose-stimulated insulin secretion by RIN-5F cells and GLUT4-mediated insulin sensitization in type 2 diabetic rat liver.

Subash-Babu, P; Ignacimuthu, S; Alshatwi, A A

Subash-Babu, P; Ignacimuthu, S; Alshatwi, A A.

Affiliation

Subash-Babu P; Department of Food Sciences and Nutrition, College of Food Sciences and Agriculture, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Ignacimuthu S; Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India.
Alshatwi AA; Department of Food Sciences and Nutrition, College of Food Sciences and Agriculture, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia. Electronic address: sbpandurangan@ksu.edu.sa.

Chem Biol Interact ; 226: 72-81, 2015 Jan 25.

Article in En | MEDLINE | ID: mdl-25499137

Subject(s)

Diabetes Mellitus, Type 2/drug therapy; Glucose Transporter Type 4/metabolism; Glucose/pharmacology; Insulin Resistance; Insulin/metabolism; Liver/drug effects; Phytosterols/pharmacology; Animals; Biological Transport/drug effects; Blood Glucose/metabolism; Body Weight/drug effects; Cell Line; Cell Proliferation/drug effects; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Experimental/enzymology; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Type 2/enzymology; Diabetes Mellitus, Type 2/metabolism; Diabetes Mellitus, Type 2/pathology; Drinking/drug effects; Gene Expression Regulation/drug effects; Glycated Hemoglobin/metabolism; Glycogen/metabolism; Insulin/blood; Insulin Receptor Substrate Proteins/metabolism; Insulin Secretion; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Insulin-Secreting Cells/pathology; Liver/enzymology; Liver/metabolism; Male; Muscle Fibers, Skeletal/drug effects; Muscle Fibers, Skeletal/metabolism; Phytosterols/therapeutic use; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism

Key words

Glucose sensitivity; Insulin secretion; Liver glycogen; Nymphaea stellata; Nymphayol; Streptozotocin

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Full text: 1 Database: MEDLINE Main subject: Phytosterols / Insulin Resistance / Diabetes Mellitus, Type 2 / Glucose Transporter Type 4 / Glucose / Insulin / Liver Language: En Journal: Chem Biol Interact Year: 2015 Type: Article Affiliation country: Saudi Arabia

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