Your browser doesn't support javascript.
loading
Two new lignans from Saururus chinensis and their DGAT inhibitory activity.
Li, Na; Tuo, Zhen-Dong; Qi, Shi-Zhou; Xing, Shan-Shan; Lee, Hyun-Sun; Chen, Jian-Guang; Cui, Long.
Affiliation
  • Li N; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
  • Tuo ZD; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
  • Qi SZ; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
  • Xing SS; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
  • Lee HS; Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 685-1 Yangcheongri, Ochangeup, Cheongwongun, Chungbuk 363-883, Republic of Korea.
  • Chen JG; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
  • Cui L; College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China. Electronic address: cuilong71@beihua.edu.cn.
Fitoterapia ; 101: 46-50, 2015 Mar.
Article in En | MEDLINE | ID: mdl-25549927
ABSTRACT
Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3±1.5 to 87.5±1.3µM.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Lignans / Saururaceae / Enzyme Inhibitors / Diacylglycerol O-Acyltransferase Language: En Journal: Fitoterapia Year: 2015 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Lignans / Saururaceae / Enzyme Inhibitors / Diacylglycerol O-Acyltransferase Language: En Journal: Fitoterapia Year: 2015 Type: Article