Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair.

Alonso-González, Carolina; González, Alicia; Martínez-Campa, Carlos; Gómez-Arozamena, José; Cos, Samuel

Alonso-González, Carolina; González, Alicia; Martínez-Campa, Carlos; Gómez-Arozamena, José; Cos, Samuel.

Affiliation

Alonso-González C; Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain.

J Pineal Res ; 58(2): 189-97, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25623566

Subject(s)

Breast Neoplasms/metabolism; DNA Repair/drug effects; DNA Repair/radiation effects; Melatonin/pharmacology; Radiation, Ionizing; Breast Neoplasms/genetics; Cell Cycle/drug effects; Cell Cycle/radiation effects; Cell Proliferation/drug effects; Cell Proliferation/radiation effects; DNA Breaks, Double-Stranded; Female; Humans; MCF-7 Cells; Rad51 Recombinase/genetics; Rad51 Recombinase/metabolism

Key words

DNA-PKcs; MCF-7 cells; RAD51; breast cancer; melatonin; pineal gland; radiation

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Full text: 1 Database: MEDLINE Main subject: Radiation, Ionizing / Breast Neoplasms / DNA Repair / Melatonin Language: En Journal: J Pineal Res Year: 2015 Type: Article Affiliation country: Spain

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