AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia.

Lehto, Sonya G; Weyer, Andy D; Zhang, Maosheng; Youngblood, Beth D; Wang, Judy; Wang, Weiya; Kerstein, Patrick C; Davis, Carl; Wild, Kenneth D; Stucky, Cheryl L; Gavva, Narender R

Lehto, Sonya G; Weyer, Andy D; Zhang, Maosheng; Youngblood, Beth D; Wang, Judy; Wang, Weiya; Kerstein, Patrick C; Davis, Carl; Wild, Kenneth D; Stucky, Cheryl L; Gavva, Narender R.

Affiliation

Lehto SG; Department of Neuroscience, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320-1799, USA, slehto@amgen.com.

Naunyn Schmiedebergs Arch Pharmacol ; 388(4): 465-76, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25662185

Subject(s)

Hyperalgesia/drug therapy; Naphthyridines/pharmacology; Naphthyridines/therapeutic use; TRPM Cation Channels/antagonists & inhibitors; Action Potentials/drug effects; Animals; Behavior, Animal/drug effects; Blood Pressure/drug effects; Brain/metabolism; CHO Cells; Calcium/metabolism; Cold Temperature; Cricetinae; Cricetulus; Freund's Adjuvant; Humans; Male; Menthol/pharmacology; Mice, Inbred C57BL; Pain/drug therapy; Pyrimidinones; Rats; Rats, Sprague-Dawley; Sciatic Nerve/injuries

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Full text: 1 Database: MEDLINE Main subject: TRPM Cation Channels / Hyperalgesia / Naphthyridines Type of study: Prognostic_studies Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2015 Type: Article

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