In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito, Lucia; Fakira, Amanda K; Cabañero, David; Blandón, Rebecca; Carlton, Susan M; Morón, Jose A; Melyan, Zara

Hipólito, Lucia; Fakira, Amanda K; Cabañero, David; Blandón, Rebecca; Carlton, Susan M; Morón, Jose A; Melyan, Zara.

Affiliation

Hipólito L; Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.

Pain ; 156(5): 849-858, 2015 May.

Article in En | MEDLINE | ID: mdl-25734988

Subject(s)

Indoles/pharmacology; Inflammation/chemically induced; Oximes/pharmacology; Pain/drug therapy; Posterior Horn Cells/drug effects; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Small-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors; Animals; Disease Models, Animal; Freund's Adjuvant/toxicity; Indoles/administration & dosage; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/physiopathology; Injections, Spinal; Male; Oximes/administration & dosage; Pain/chemically induced; Pain/metabolism; Pain/physiopathology; Pain Threshold; Posterior Horn Cells/metabolism; Rats; Rats, Sprague-Dawley; Spinal Cord/cytology; Treatment Outcome

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Oximes / Pain / Receptors, N-Methyl-D-Aspartate / Posterior Horn Cells / Small-Conductance Calcium-Activated Potassium Channels / Indoles / Inflammation Language: En Journal: Pain Year: 2015 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google