Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.

Takeuchi, Kenji; Goto, Hirohiko; Ito, Yuko; Sato, Makoto; Matsumoto, Satoshi; Senba, Tadashi; Yamada, Hideyuki; Umehara, Ken

Takeuchi, Kenji; Goto, Hirohiko; Ito, Yuko; Sato, Makoto; Matsumoto, Satoshi; Senba, Tadashi; Yamada, Hideyuki; Umehara, Ken.

Affiliation

Takeuchi K; Department of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan; Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

J Toxicol Sci ; 40(2): 181-91, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25786523

Subject(s)

Cytochrome P-450 Enzyme Inducers/therapeutic use; Cytochrome P-450 Enzyme System/metabolism; Dehydroepiandrosterone Sulfate/therapeutic use; Fatty Liver/chemically induced; Fatty Liver/drug therapy; Methylcholanthrene/therapeutic use; Orotic Acid/adverse effects; Phenobarbital/therapeutic use; Animals; Cytochrome P-450 Enzyme Inducers/pharmacology; Dehydroepiandrosterone Sulfate/pharmacology; Drug Therapy, Combination; Fatty Acids/metabolism; Fatty Liver/enzymology; Fatty Liver/pathology; Liver/enzymology; Liver/pathology; Male; Methylcholanthrene/pharmacology; Orotic Acid/antagonists & inhibitors; Oxidation-Reduction/drug effects; Peroxisomes/pathology; Phenobarbital/pharmacology; Rats, Sprague-Dawley; Sirtuin 1/metabolism

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Full text: 1 Database: MEDLINE Main subject: Orotic Acid / Phenobarbital / Dehydroepiandrosterone Sulfate / Cytochrome P-450 Enzyme System / Fatty Liver / Cytochrome P-450 Enzyme Inducers / Methylcholanthrene Language: En Journal: J Toxicol Sci Year: 2015 Type: Article Affiliation country: Japan

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