A UPLC-MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma: application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract.

Ai, Yu; Wu, Yun; Wang, Fenrong; Ma, Wen; Bian, Qiaoxia; Lee, David Y-W; Dai, Ronghua

Ai, Yu; Wu, Yun; Wang, Fenrong; Ma, Wen; Bian, Qiaoxia; Lee, David Y-W; Dai, Ronghua.

Affiliation

Ai Y; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.

J Mass Spectrom ; 50(3): 567-77, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25800193

Subject(s)

Berberine Alkaloids/blood; Chromatography, High Pressure Liquid/methods; Drugs, Chinese Herbal/pharmacokinetics; Glucosides/blood; Monoterpenes/blood; Tandem Mass Spectrometry/methods; Animals; Berberine Alkaloids/chemistry; Berberine Alkaloids/pharmacokinetics; Drug Stability; Drugs, Chinese Herbal/administration & dosage; Drugs, Chinese Herbal/chemistry; Glucosides/chemistry; Glucosides/pharmacokinetics; Linear Models; Male; Monoterpenes/chemistry; Monoterpenes/pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity

Key words

Huo Luo Xiao Ling Dan; UPLC-MS/MS; alkaloids; monoterpene glycosides; pharmacokinetics

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Berberine Alkaloids / Drugs, Chinese Herbal / Chromatography, High Pressure Liquid / Monoterpenes / Tandem Mass Spectrometry / Glucosides Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Mass Spectrom Year: 2015 Type: Article Affiliation country: China

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