Urine angiotensinogen and salt-sensitivity and potassium-sensitivity of blood pressure.
J Hypertens
; 33(7): 1394-400, 2015 Jul.
Article
in En
| MEDLINE
| ID: mdl-25827430
ABSTRACT
OBJECTIVE:
Urinary excretion of angiotensinogen [urine angiotensinogen (UAGT)] has been proposed as a biomarker of intrarenal renin-angiotensin system activity. We investigated the association between UAGT and salt-sensitivity and potassium-sensitivity of blood pressure (BP) among Genetic Epidemiology Network of Salt Sensitivity study participants.METHODS:
The intervention consisted of a 7-day low-sodium diet (51.3 âmmol sodium/day), 7-day high-sodium diet (307.8â mmol sodium/day), and 7-day high-sodium diet with potassium supplementation (307.8â mmol sodium/day and 60 âmmol potassium/day). Twenty-four-hour UAGT was estimated at baseline and at the end of each intervention for 100 randomly selected participants.RESULTS:
Median UAGT (µg/24â h) and UAGT-to-creatinine ratio (UAGT/Cr, µg/g) were significantly reduced during the low-sodium and potassium-supplementation interventions and increased during the high-sodium intervention (both Pâ=â0.01). Baseline log-transformed UAGT and UAGT/Cr ratio were significantly positively associated with BP at baseline and at the end of each intervention. For example, one standard deviation higher log-UAGT/Cr ratio (1.2 âµg/g) was associated with a 5.0-mmHg (95% confidence interval 2.3-7.8) higher SBP at the end of the high-sodium intervention, after adjusting for multiple covariates (Pâ=â0.003). In addition, one standard deviation higher log-UAGT/Cr ratio was associated with a 1.6-mmHg increase in age-adjusted and sex-adjusted SBP from the low-sodium intervention to the high-sodium intervention (95% confidence interval 0.1-3.1, Pâ=â0.04). This association was no longer statistically significant after multivariable adjustment.CONCLUSION:
These data indicate that elevated UAGT are associated with BP sodium sensitivity. Augmentation of intrarenal renin-angiotensin system activity may play an important role in developing salt-sensitive hypertension.
Full text:
1
Database:
MEDLINE
Main subject:
Potassium
/
Blood Pressure
/
Angiotensinogen
/
Sodium Chloride, Dietary
/
Hypertension
Type of study:
Diagnostic_studies
Language:
En
Journal:
J Hypertens
Year:
2015
Type:
Article
Affiliation country:
China