Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-&#954;B signal pathways.

Zhang, Xiuli; Li, Chunli; Li, Jun; Xu, Yingzhen; Guan, Shui; Zhao, Mingshan

Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways.

Zhang, Xiuli; Li, Chunli; Li, Jun; Xu, Yingzhen; Guan, Shui; Zhao, Mingshan.

Affiliation

Zhang X; School of Pharmaceutical Sciences Binzhou Medical University, Yantai, Shandong 264003, China. Electronic address: zhangxiuli2008@163.com.
Li C; School of Pharmaceutical Sciences Binzhou Medical University, Yantai, Shandong 264003, China.
Li J; School of Pharmaceutical Sciences Binzhou Medical University, Yantai, Shandong 264003, China.
Xu Y; Stem Cell and Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116024, China.
Guan S; Stem Cell and Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116024, China.
Zhao M; School of Pharmaceutical Sciences Binzhou Medical University, Yantai, Shandong 264003, China.

Int Immunopharmacol ; 26(1): 229-36, 2015 May.

Article in En | MEDLINE | ID: mdl-25841318

Subject(s)

Acute Lung Injury/drug therapy; Anti-Inflammatory Agents/therapeutic use; Drugs, Chinese Herbal/therapeutic use; Hydroxybenzoates/therapeutic use; NF-kappa B/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Acute Lung Injury/enzymology; Acute Lung Injury/immunology; Acute Lung Injury/pathology; Animals; Anti-Inflammatory Agents/administration & dosage; Blotting, Western; Bronchoalveolar Lavage Fluid/chemistry; Cytokines/blood; Disease Models, Animal; Drugs, Chinese Herbal/administration & dosage; Hydroxybenzoates/administration & dosage; Lipopolysaccharides/pharmacology; Male; Mice, Inbred Strains; Real-Time Polymerase Chain Reaction; Signal Transduction/drug effects

Key words

Acute lung injury (ALI); Lipopolysaccharide (LPS); Nuclear transcription factor kappa B; Protocatechuic acid (PCA); p38 mitogen-activating protein kinase

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Drugs, Chinese Herbal / NF-kappa B / P38 Mitogen-Activated Protein Kinases / Acute Lung Injury / Hydroxybenzoates / Anti-Inflammatory Agents Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Year: 2015 Type: Article

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