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Danggui buxue tang inhibits 2,4-dinitrochlorobenzene: induced atopic dermatitis in mice.
Fang, Li-Wen; Cheng, Chao-Chun; Hwang, Tzann-Shun; Huang, Wen-Chung; Liou, Chian-Jiun; Chen, Wen-Chyuan; Wu, Shu-Ju.
Affiliation
  • Fang LW; Department of Nutrition, I-Shou University, Yanchao District, Kaohsiung City, Taiwan.
  • Cheng CC; Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Nutritional Science Department, Fu Jen Catholic University, New Taipei City, Taiwan.
  • Hwang TS; Graduate Institute of Biotechnology, Chinese Culture University, Yang-Ming-Shan, Taipei, Taiwan.
  • Huang WC; Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
  • Liou CJ; Department of Nursing, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
  • Chen WC; Center for General Education, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
  • Wu SJ; Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
Article in En | MEDLINE | ID: mdl-25861366
Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice. The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene. Mice were then given various doses of DBT from days 14 to 29 cutaneously. DBT treatment suppressed ear swelling and skin inflammation and decreased mast cell and eosinophil infiltration into skin and ear tissue. DBT also inhibited levels of IgE and Th2-associated cytokine levels in serum. These results demonstrate that cutaneous administration of DBT reduced the development of AD-like skin lesions in mice.

Full text: 1 Database: MEDLINE Language: En Journal: Evid Based Complement Alternat Med Year: 2015 Type: Article Affiliation country: Taiwan

Full text: 1 Database: MEDLINE Language: En Journal: Evid Based Complement Alternat Med Year: 2015 Type: Article Affiliation country: Taiwan