The effects of tissue-non-specific alkaline phosphatase gene therapy on craniosynostosis and craniofacial morphology in the FGFR2C342Y/+ mouse model of Crouzon craniosynostosis.

Wang, E; Nam, H K; Liu, J; Hatch, N E

Wang, E; Nam, H K; Liu, J; Hatch, N E.

Affiliation

Wang E; Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Orthod Craniofac Res ; 18 Suppl 1: 196-206, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25865549

Subject(s)

Alkaline Phosphatase/genetics; Craniosynostoses/therapy; Genetic Therapy; Receptor, Fibroblast Growth Factor, Type 2/genetics; Skull/pathology; Alkaline Phosphatase/blood; Animals; Calcification, Physiologic/genetics; Calcium/blood; Cephalometry/methods; Cranial Sutures/growth & development; Cranial Sutures/pathology; Craniosynostoses/physiopathology; Cysteine/genetics; Disease Models, Animal; Female; Genetic Vectors/genetics; Lentivirus/genetics; Male; Mice; Mice, Inbred BALB C; Occipital Bone/growth & development; Occipital Bone/pathology; Parietal Bone/growth & development; Parietal Bone/pathology; Phosphorus/blood; Signal Transduction/genetics; Skull/growth & development; Tyrosine/genetics; X-Ray Microtomography/methods

Key words

bone; craniofacial; craniosynostosis; mineralization; mouse model

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Full text: 1 Database: MEDLINE Main subject: Skull / Genetic Therapy / Craniosynostoses / Alkaline Phosphatase / Receptor, Fibroblast Growth Factor, Type 2 Type of study: Prognostic_studies Language: En Journal: Orthod Craniofac Res Year: 2015 Type: Article Affiliation country: United States

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