Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition.
Biofactors
; 41(3): 190-7, 2015 May 06.
Article
in En
| MEDLINE
| ID: mdl-25963419
Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Taurine
/
Bone and Bones
/
Bone Development
/
Diet, Protein-Restricted
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Dietary Supplements
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Malnutrition
Type of study:
Etiology_studies
/
Prognostic_studies
Language:
En
Journal:
Biofactors
Year:
2015
Type:
Article