Effect of High Fat Diets on Body Mass, Oleylethanolamide Plasma Levels and Oxytocin Expression in Growing Rats.
J Food Sci
; 80(6): H1425-31, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25976631
ABSTRACT
Obesity prevalence in developed countries has promoted the need to identify the mechanisms involved in control of feeding and energy balance. We have tested the hypothesis that different fats present in diet composition may contribute in body weight gain and body indexes by regulation of oxytocin gene (oxt) expression in hypothalamus and Oleylethanolamide (OEA) levels in plasma. Sprague-Dawley rats were fed two high fat diets, based on corn (HCO) and extra virgin olive oil (HOO) and results were compared to a low fat diet (LF). LC-MS/MS analysis showed an increasing trend of OEA plasma levels in HOO group, although no significant differences were found. However, body weight gain of LF and HOO were similar and significantly lower than HCO. HCO rats also had higher Lee index than HOO. Rats fed HOO diet showed higher levels of hypothalamic oxt mRNA expression, which could indicate that oxytocin may be modulated by dietary lipids.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Oxytocin
/
Oleic Acids
/
Diet, High-Fat
Type of study:
Risk_factors_studies
Language:
En
Journal:
J Food Sci
Year:
2015
Type:
Article
Affiliation country:
Spain