Ciprofloxacin Therapy Results in Mitigation of ATP Loss after Irradiation Combined with Wound Trauma: Preservation of Pyruvate Dehydrogenase and Inhibition of Pyruvate Dehydrogenase Kinase 1.

Swift, Joshua M; Smith, Joan T; Kiang, Juliann G

Swift, Joshua M; Smith, Joan T; Kiang, Juliann G.

Affiliation

Swift JM; a Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889; and.
Smith JT; b Departments of Military and Emergency Medicine;
Kiang JG; c Radiation Biology and.

Radiat Res ; 183(6): 684-92, 2015 Jun.

Article in En | MEDLINE | ID: mdl-26010714

Subject(s)

Adenosine Triphosphate/metabolism; Ciprofloxacin/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Pyruvate Dehydrogenase Complex/metabolism; Radiation Injuries, Experimental/complications; Radiation Injuries, Experimental/drug therapy; Wounds and Injuries/complications; Administration, Oral; Animals; Ciprofloxacin/administration & dosage; Ciprofloxacin/therapeutic use; Female; Gamma Rays/adverse effects; HSP70 Heat-Shock Proteins/metabolism; HSP90 Heat-Shock Proteins/metabolism; Ileum/drug effects; Ileum/metabolism; Ileum/radiation effects; Mice; Phosphorylation/drug effects; Phosphorylation/radiation effects; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Serine-Threonine Kinases/chemistry; Protein Serine-Threonine Kinases/metabolism; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Radiation Injuries, Experimental/enzymology; Radiation Injuries, Experimental/metabolism; Serine/metabolism

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Pyruvate Dehydrogenase Complex / Radiation Injuries, Experimental / Wounds and Injuries / Ciprofloxacin / Adenosine Triphosphate / Protein Serine-Threonine Kinases Language: En Journal: Radiat Res Year: 2015 Type: Article

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