Discovery of xanthine oxidase inhibitors and/or &#945;-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.

Su, Zhuo-Ran; Fan, Shi-Yong; Shi, Wei-Guo; Zhong, Bo-Hua

Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.

Su, Zhuo-Ran; Fan, Shi-Yong; Shi, Wei-Guo; Zhong, Bo-Hua.

Affiliation

Su ZR; Beijing Institute of Pharmacology & Toxicology, 27th Taiping Road, Beijing 100850, China.
Fan SY; Beijing Institute of Pharmacology & Toxicology, 27th Taiping Road, Beijing 100850, China.
Shi WG; Beijing Institute of Pharmacology & Toxicology, 27th Taiping Road, Beijing 100850, China.
Zhong BH; Beijing Institute of Pharmacology & Toxicology, 27th Taiping Road, Beijing 100850, China. Electronic address: bohuazhong@yahoo.com.

Bioorg Med Chem Lett ; 25(14): 2778-81, 2015 Jul 15.

Article in En | MEDLINE | ID: mdl-26022844

Subject(s)

Apigenin/chemistry; Glycoside Hydrolase Inhibitors/chemistry; Hypoglycemic Agents/chemistry; Xanthine Oxidase/antagonists & inhibitors; alpha-Glucosidases/chemistry; Animals; Apigenin/metabolism; Apigenin/therapeutic use; Disease Models, Animal; Drug Evaluation, Preclinical; Flavonoids/chemistry; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors/metabolism; Glycoside Hydrolase Inhibitors/therapeutic use; Hyperuricemia/chemically induced; Hyperuricemia/drug therapy; Hypoglycemic Agents/metabolism; Hypoglycemic Agents/therapeutic use; Infusions, Parenteral; Mice; Protein Binding; Structure-Activity Relationship; Uric Acid/blood; Xanthine Oxidase/metabolism; alpha-Glucosidases/metabolism

Key words

Apigenin; Diabetes; Gout; Xanthine oxidase; α-Glucosidase

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Full text: 1 Database: MEDLINE Main subject: Xanthine Oxidase / Apigenin / Alpha-Glucosidases / Glycoside Hydrolase Inhibitors / Hypoglycemic Agents Language: En Journal: Bioorg Med Chem Lett Year: 2015 Type: Article Affiliation country: China

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