Wilfordonols A-D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii.
J Asian Nat Prod Res
; 17(6): 615-24, 2015.
Article
in En
| MEDLINE
| ID: mdl-26096035
ABSTRACT
Four new norsesquiterpenes wilfordonols A-D (1-4), along with three known compounds, sarmentol B (5), boscialin (6), and (+)-loliolide (7), were isolated from the leaves of Tripterygium wilfordii Hook.f.. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of the compounds was confirmed by CD and modified Mosher's method. At a concentration of 10 µM, compounds 4, 6, and 7 inhibited signal transducer and activator of transcription 1 translocation by 34.27 ± 1.02%, 48.93 ± 1.76%, and 70.31 ± 2.20%, respectively.
Key words
Full text:
1
Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Sesquiterpenes
/
Drugs, Chinese Herbal
/
Tripterygium
Language:
En
Journal:
J Asian Nat Prod Res
Year:
2015
Type:
Article
Affiliation country:
China