Renal targeted delivery of triptolide by conjugation to the fragment peptide of human serum albumin.

Yuan, Zhi-xiang; Wu, Xiao-juan; Mo, Jingxin; Wang, Yan-li; Xu, Chao-qun; Lim, Lee Yong

Yuan, Zhi-xiang; Wu, Xiao-juan; Mo, Jingxin; Wang, Yan-li; Xu, Chao-qun; Lim, Lee Yong.

Affiliation

Yuan ZX; Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu, Sichuan 610041, China.
Wu XJ; Integrative Traditional and Western Medicine Hospital of Sichuan Province, Chengdu, Sichuan 610041, China.
Mo J; Pharmacy, School of Medicine and Pharmacology, The University of Western Australia, Western Australia 6009, Australia.
Wang YL; Department of Nutrition, Sichuan Provincial Hospital for Women and Children, Chengdu, Sichuan 610041, China.
Xu CQ; Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu, Sichuan 610041, China. Electronic address: chaoqun_xu@sina.com.
Lim LY; Pharmacy, School of Medicine and Pharmacology, The University of Western Australia, Western Australia 6009, Australia. Electronic address: lee.lim@uwa.edu.au.

Eur J Pharm Biopharm ; 94: 363-71, 2015 Aug.

Article in En | MEDLINE | ID: mdl-26117184

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Diterpenes/administration & dosage; Drug Delivery Systems/methods; Kidney/drug effects; Peptide Fragments/chemistry; Phenanthrenes/administration & dosage; Serum Albumin/chemistry; Animals; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Anti-Inflammatory Agents, Non-Steroidal/toxicity; Cell Survival/drug effects; Diterpenes/chemistry; Diterpenes/therapeutic use; Diterpenes/toxicity; Dogs; Drug Liberation; Epoxy Compounds/administration & dosage; Epoxy Compounds/chemistry; Epoxy Compounds/therapeutic use; Epoxy Compounds/toxicity; Glomerulonephritis, Membranous/drug therapy; Glomerulonephritis, Membranous/metabolism; Humans; Kidney/metabolism; Madin Darby Canine Kidney Cells; Male; Medicine, Chinese Traditional; Mice, Inbred Strains; Phenanthrenes/chemistry; Phenanthrenes/therapeutic use; Phenanthrenes/toxicity; Rats, Sprague-Dawley

Key words

Conjugate; Fragment peptide; Human serum albumin; Renal targeting; Triptolide

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Peptide Fragments / Phenanthrenes / Serum Albumin / Anti-Inflammatory Agents, Non-Steroidal / Drug Delivery Systems / Diterpenes / Kidney Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Eur J Pharm Biopharm Year: 2015 Type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google