Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query.

Basant, Nikita; Lin, Xionghao; Reid, Terry-Elinor; Karla, Pradeep K; Wang, Xiang S

Basant, Nikita; Lin, Xionghao; Reid, Terry-Elinor; Karla, Pradeep K; Wang, Xiang S.

Affiliation

Wang XS; Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, 2300 4th St. NW, Washington, DC 20059, USA. x.simon.wang@gmail.com.

Comb Chem High Throughput Screen ; 18(7): 693-700, 2015.

Article in En | MEDLINE | ID: mdl-26144283

Subject(s)

Aniline Compounds/chemistry; Drug Discovery; Drug Evaluation, Preclinical; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Aniline Compounds/pharmacology; Catalytic Domain; Enzyme Activation/drug effects; Histone Deacetylase Inhibitors/chemistry; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation

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Full text: 1 Database: MEDLINE Main subject: Drug Evaluation, Preclinical / Drug Discovery / Histone Deacetylase Inhibitors / Histone Deacetylases / Aniline Compounds Language: En Journal: Comb Chem High Throughput Screen Year: 2015 Type: Article

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