Hypothalamic inflammation and food intake regulation during chronic illness.
Peptides
; 77: 60-6, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-26158772
ABSTRACT
Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly affects survival and quality of life. A common denominator of many chronic diseases is an elevated inflammatory status, which is considered to play a pivotal role in the failure of food-intake regulating systems in the hypothalamus. In this review, we summarize findings on the role of hypothalamic inflammation on food intake regulation involving hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role of serotonin in the inability of these peptide based food-intake regulating systems to respond and adapt to changes in energy metabolism during chronic disease.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Appetite Regulation
/
Hypothalamus
/
Neoplasms
Language:
En
Journal:
Peptides
Year:
2016
Type:
Article