Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice.

Pandey, Surya P; Singh, Hemant K; Prasad, S

Pandey, Surya P; Singh, Hemant K; Prasad, S.

Affiliation

Pandey SP; Biochemistry & Molecular Biology Lab, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Singh HK; Lumen Research Foundation, Ashok Nagar, Chennai, 600083, Tamilnadu, India.
Prasad S; Biochemistry & Molecular Biology Lab, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.

PLoS One ; 10(7): e0131862, 2015.

Article in En | MEDLINE | ID: mdl-26161865

Subject(s)

CA3 Region, Hippocampal/metabolism; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Type 2/metabolism; Hypoglycemic Agents/pharmacology; Plant Extracts/pharmacology; Receptors, AMPA/metabolism; Animals; Bacopa/chemistry; CA3 Region, Hippocampal/drug effects; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Experimental/psychology; Diabetes Mellitus, Type 2/drug therapy; Diabetes Mellitus, Type 2/psychology; Drug Evaluation, Preclinical; Gene Expression/drug effects; Hypoglycemic Agents/therapeutic use; Male; Malondialdehyde/metabolism; Maze Learning; Memory Disorders/drug therapy; Memory Disorders/metabolism; Mice; Oxidative Stress; Plant Extracts/therapeutic use; Receptors, AMPA/genetics; Spatial Memory/drug effects; Streptozocin

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Full text: 1 Database: MEDLINE Main subject: Plant Extracts / Receptors, AMPA / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / CA3 Region, Hippocampal / Hypoglycemic Agents Type of study: Risk_factors_studies Language: En Journal: PLoS One Year: 2015 Type: Article Affiliation country: India

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