Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targets.

Zhao, Hui; Zhou, Lyu; Zhang, Qiang; Zhou, Xiaoying; Zhang, Yonghui; Chen, Huijun; Du, Yanan

Zhao, Hui; Zhou, Lyu; Zhang, Qiang; Zhou, Xiaoying; Zhang, Yonghui; Chen, Huijun; Du, Yanan.

Affiliation

Zhao H; School of Life Sciences, Tsinghua University, Beijing, 10084, China.

Lab Chip ; 15(17): 3481-94, 2015 Sep 07.

Article in En | MEDLINE | ID: mdl-26219255

Subject(s)

Collagen/chemistry; Cytoskeleton/drug effects; Drug Discovery/instrumentation; Drug Evaluation, Preclinical/instrumentation; Drug Evaluation, Preclinical/methods; Microchip Analytical Procedures; Animals; Cell Line, Tumor; Equipment Design; Fibroblasts/chemistry; Fibroblasts/cytology; Humans; Rats; Tissue Array Analysis

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Full text: 1 Database: MEDLINE Main subject: Cytoskeleton / Collagen / Microchip Analytical Procedures / Drug Evaluation, Preclinical / Drug Discovery Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Lab Chip Year: 2015 Type: Article Affiliation country: China

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