Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer.
Anticancer Res
; 35(9): 4997-5005, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26254399
ABSTRACT
BACKGROUND:
To assess impact of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients treated for a first relapse of ovarian cancer (FROC). PATIENTS ANDMETHODS:
Patients with a FROC treated with second-line chemotherapy, surgery and HIPEC were retrospectively included from 13 Institutions. Studied parameters were interval free between the end of initial treatment and the first relapse, second-line chemotherapy, peritoneal cancer index and completeness of surgery, HIPEC, mortality and morbidity, pathological results and survival.RESULTS:
From 2001 to 2010, 314 patients were included. The main strategy was secondary chemotherapy followed by surgery and HIPEC (269/314-85.6%). Mortality and morbidity rates were respectively 1% and 30.9%. Median follow-up was 50 months, 5-year overall survival was 38.0%, with no difference between platinum-sensitive or -resistant patients and 5-year disease-free survival was 14%.CONCLUSION:
HIPEC allows encouraging survival in the treatment of FROC, better in case of complete surgery, with acceptable mortality and morbidity rates.Key words
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Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Cytoreduction Surgical Procedures
/
Hyperthermia, Induced
Type of study:
Clinical_trials
/
Observational_studies
Language:
En
Journal:
Anticancer Res
Year:
2015
Type:
Article
Affiliation country:
France