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Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy.
Koplin, Jennifer J; Suaini, Noor H A; Vuillermin, Peter; Ellis, Justine A; Panjari, Mary; Ponsonby, Anne-Louise; Peters, Rachel L; Matheson, Melanie C; Martino, David; Dang, Thanh; Osborne, Nicholas J; Martin, Pamela; Lowe, Adrian; Gurrin, Lyle C; Tang, Mimi L K; Wake, Melissa; Dwyer, Terry; Hopper, John; Dharmage, Shyamali C; Allen, Katrina J.
Affiliation
  • Koplin JJ; Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Suaini NH; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Vuillermin P; Murdoch Childrens Research Institute, Parkville, Australia; Child Health Research Unit, Barwon Health and Deakin University, Geelong, Australia.
  • Ellis JA; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Panjari M; Murdoch Childrens Research Institute, Parkville, Australia.
  • Ponsonby AL; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Peters RL; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Matheson MC; Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Martino D; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Dang T; Murdoch Childrens Research Institute, Parkville, Australia.
  • Osborne NJ; European Centre for Environment and Human Health, University of Exeter Medical School, Cornwall, United Kingdom.
  • Martin P; Murdoch Childrens Research Institute, Parkville, Australia.
  • Lowe A; Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Gurrin LC; Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Tang ML; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia.
  • Wake M; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Centre for Community Child Health, Royal Children's Hospital, Parkville, Australia.
  • Dwyer T; Murdoch Childrens Research Institute, Parkville, Australia.
  • Hopper J; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Dharmage SC; Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
  • Allen KJ; Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia; School of Inflammation and Repair, University of Manchester, Manchester, United
J Allergy Clin Immunol ; 137(2): 500-506.e4, 2016 Feb.
Article in En | MEDLINE | ID: mdl-26260969
ABSTRACT

BACKGROUND:

There is evolving evidence that vitamin D insufficiency may contribute to food allergy, but findings vary between populations. Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels.

OBJECTIVE:

We sought to investigate whether polymorphisms that lower the DBP could compensate for adverse effects of low serum vitamin D on food allergy risk.

METHODS:

From a population-based cohort study (n = 5276) we investigated the association between serum 25-hydroxyvitamin D3 (25[OH]D3) levels and food allergy at age 1 year (338 challenge-proven food-allergic and 269 control participants) and age 2 years (55 participants with persistent and 50 participants with resolved food allergy). 25(OH)D3 levels were measured using liquid chromatography-tandem mass spectrometry and adjusted for season of blood draw. Analyses were stratified by genotype at rs7041 as a proxy marker of DBP levels (low, the GT/TT genotype; high, the GG genotype).

RESULTS:

Low serum 25(OH)D3 level (≤50 nM/L) at age 1 years was associated with food allergy, particularly among infants with the GG genotype (odds ratio [OR], 6.0; 95% CI, 0.9-38.9) but not in those with GT/TT genotypes (OR, 0.7; 95% CI, 0.2-2.0; P interaction = .014). Maternal antenatal vitamin D supplementation was associated with less food allergy, particularly in infants with the GT/TT genotype (OR, 0.10; 95% CI, 0.03-0.41). Persistent vitamin D insufficiency increased the likelihood of persistent food allergy (OR, 12.6; 95% CI, 1.5-106.6), particularly in those with the GG genotype.

CONCLUSIONS:

Polymorphisms associated with lower DBP level attenuated the association between low serum 25(OH)D3 level and food allergy, consistent with greater vitamin D bioavailability in those with a lower DBP level. This increases the biological plausibility of a role for vitamin D in the development of food allergy.
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Full text: 1 Database: MEDLINE Main subject: Vitamin D-Binding Protein / Calcifediol / Polymorphism, Single Nucleotide / Genetic Association Studies / Food Hypersensitivity Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Screening_studies Language: En Journal: J Allergy Clin Immunol Year: 2016 Type: Article Affiliation country: Australia
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Full text: 1 Database: MEDLINE Main subject: Vitamin D-Binding Protein / Calcifediol / Polymorphism, Single Nucleotide / Genetic Association Studies / Food Hypersensitivity Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Screening_studies Language: En Journal: J Allergy Clin Immunol Year: 2016 Type: Article Affiliation country: Australia