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A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.
Blobaum, Anna L; Byers, Frank W; Bridges, Thomas M; Locuson, Charles W; Conn, P Jeffrey; Lindsley, Craig W; Daniels, J Scott.
Affiliation
  • Blobaum AL; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.) annie.blobaum@vanderbilt.edu.
  • Byers FW; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
  • Bridges TM; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
  • Locuson CW; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
  • Conn PJ; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
  • Lindsley CW; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
  • Daniels JS; Departments of Pharmacology (A.L.B., F.W.B., T.M.B., C.W.L., P.J.C., C.W.L, J.S.D) and Chemistry (C.W.L), Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, Tennessee (C.W.L.).
Drug Metab Dispos ; 43(11): 1718-26, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26265743
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Full text: 1 Database: MEDLINE Main subject: Enzyme Activators / Cytochrome P-450 CYP3A / Androgen Receptor Antagonists / Flutamide Type of study: Prognostic_studies Language: En Journal: Drug Metab Dispos Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Enzyme Activators / Cytochrome P-450 CYP3A / Androgen Receptor Antagonists / Flutamide Type of study: Prognostic_studies Language: En Journal: Drug Metab Dispos Year: 2015 Type: Article