The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial.
J Clin Anesth
; 27(7): 595-601, 2015 Nov.
Article
in En
| MEDLINE
| ID: mdl-26315876
ABSTRACT
STUDY OBJECTIVES:
We compared magnesium sulphate with control, ketamine, rocuronium prime, and large-dose rocuronium (0.9 mg/kg) with regard to intubation conditions during rapid-sequence induction.DESIGN:
This is a prospective, randomized, double-blinded study.SETTING:
The setting is at an operating room in a university-affiliated hospital. PATIENTS One hundred ten patients scheduled for general anesthesia were randomly allocated to the following 5 groups in equal numbers.INTERVENTIONS:
The control and rocuronium 0.9 groups received rocuronium 0.6 and 0.9 mg/kg, respectively; the ketamine group was given 0.5 mg/kg ketamine 2 minutes before 0.6 mg/kg rocuronium; the rocuronium prime group received 0.06 mg/kg rocuronium 3 minutes before 0.54 mg/kg rocuronium; and the magnesium group received 50 mg/kg magnesium sulphate. Intubation was initiated 50 seconds after the rocuronium injection. MEASUREMENTS Intubating condition (primary outcome), rocuronium onset, rocuronium duration, train-of-four ratio upon intubation, and hemodynamic variables (secondary outcomes) were recorded. MAINRESULTS:
The excellent intubating condition was more frequent in the magnesium group (P < .05). Onset of neuromuscular block was shorter in the magnesium group than in the control, ketamine, and rocuronium prime groups (P < .05). No difference in onset time was found between the magnesium and rocuronium 0.9 groups. Block duration was longest in the rocuronium 0.9 group. The train-of-four ratio on intubation was lowest in the rocuronium prime group. The only adverse event was a burning or heat sensation reported by 5 patients in the magnesium group.CONCLUSIONS:
Magnesium sulphate pretreatment was most likely to provide excellent intubating condition for rapid-sequence intubation compared with the control, ketamine pretreatment, rocuronium prime, and large-dose rocuronium. However, magnesium sulphate administration is associated with a burning or heat sensation.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Androstanols
/
Intubation, Intratracheal
/
Ketamine
/
Magnesium Sulfate
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Language:
En
Journal:
J Clin Anesth
Year:
2015
Type:
Article
Affiliation country:
South Korea