[Stimulating Type I interferon response with small molecules: revival of an old idea]. / Stimuler la réponse interféron de type I avec des petites molécules : le renouveau d'une vieille idée.
Biol Aujourdhui
; 209(2): 145-59, 2015.
Article
in Fr
| MEDLINE
| ID: mdl-26514384
ABSTRACT
Type I interferons play a central role in the establishment of an innate immune response against viral infections and tumor cells. Shortly after their discovery in 1957, several groups have looked for small molecules capable of inducing the expression of these cytokines with therapeutic applications in mind. A set of active compounds in mice were identified, but because of their relative inefficiency in humans for reasons not understood at the time, these studies fell into oblivion. In recent years, the characterization of pathogen recognition receptors and the signaling pathways they activate, together with the discovery of plasmacytoid dendritic cells, have revolutionized our understanding of innate immunity. These discoveries and the popularization of high-throughput screening technologies have renewed the interest for small molecules that can induce type I interferons. Proofs about their therapeutic potency in humans are expected very soon.
Full text:
1
Database:
MEDLINE
Main subject:
Interferon Type I
/
Interferon Inducers
Type of study:
Prognostic_studies
Language:
Fr
Journal:
Biol Aujourdhui
Year:
2015
Type:
Article
Affiliation country:
France