Ethyl-³H analogues of plant natural products: Biologically active proxy radioligands via vinyl group tritiation.

Orphanos, Demetri; Filer, Crist N

Orphanos, Demetri; Filer, Crist N.

Affiliation

Orphanos D; PerkinElmer Health Sciences, Inc., 940 Winter St, Waltham, MA 02451, United States.
Filer CN; PerkinElmer Health Sciences, Inc., 940 Winter St, Waltham, MA 02451, United States. Electronic address: crist.filer@perkinelmer.com.

Appl Radiat Isot ; 107: 203-205, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26520478

ABSTRACT

ABSTRACT

Methods are presented to tritiate the plant natural product analogues dihydrocolforsin and dihydroquinidine.

Subject(s)

Biological Products/chemistry; Isotope Labeling/methods; Animals; Biological Products/chemical synthesis; Catalysis; Colforsin/analogs & derivatives; Colforsin/chemical synthesis; Colforsin/chemistry; Humans; Plant Preparations/chemistry; Quinidine/analogs & derivatives; Quinidine/chemical synthesis; Quinidine/chemistry; Radioligand Assay; Radiopharmaceuticals/chemical synthesis; Radiopharmaceuticals/chemistry; Tritium/chemistry; Vinyl Compounds/chemistry

Key words

Dihydrocolforsin; Dihydroquinidine; Tritium; Tritium NMR

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Full text: 1 Database: MEDLINE Main subject: Biological Products / Isotope Labeling Language: En Journal: Appl Radiat Isot Year: 2016 Type: Article Affiliation country: United States

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