Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.
J Pharm Sci
; 105(2): 509-511, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26523769
ABSTRACT
To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tablets, Enteric-Coated
/
Calcium Chloride
Language:
En
Journal:
J Pharm Sci
Year:
2016
Type:
Article
Affiliation country:
Germany