Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/ß-endorphin pathway.

Jia, Yu; Gong, Nian; Li, Teng-Fei; Zhu, Bin; Wang, Yong-Xiang

Jia, Yu; Gong, Nian; Li, Teng-Fei; Zhu, Bin; Wang, Yong-Xiang.

Affiliation

Jia Y; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, China.
Gong N; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, China.
Li TF; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, China.
Zhu B; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, China.
Wang YX; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, China. Electronic address: yxwang@sjtu.edu.cn.

Pharmacol Res ; 102: 276-85, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26546042

Subject(s)

Glucagon-Like Peptide-1 Receptor/metabolism; Hippocampus/drug effects; Iridoid Glucosides/pharmacology; Neuroprotection/drug effects; Neuroprotective Agents/pharmacology; Peptides/pharmacology; Venoms/pharmacology; beta-Endorphin/metabolism; Animals; Cells, Cultured; Exenatide; Glucagon-Like Peptide 1/metabolism; Hippocampus/metabolism; Insulin/metabolism; Male; Microglia/drug effects; Microglia/metabolism; Neurons/drug effects; Neurons/metabolism; Rats; Rats, Wistar; Receptors, Opioid/metabolism

Key words

Catalpol; Exenatide; Glucagon-like peptide-1 receptor (GLP-1R); Microglia; Neuroprotection; ß-endorphin

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Full text: 1 Database: MEDLINE Main subject: Peptides / Venoms / Beta-Endorphin / Neuroprotective Agents / Iridoid Glucosides / Glucagon-Like Peptide-1 Receptor / Neuroprotection / Hippocampus Language: En Journal: Pharmacol Res Year: 2015 Type: Article Affiliation country: China

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