Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid ß-induced impairment of learning and memory in rats.

Ma, Qin; Ruan, Ying-ying; Xu, Hui; Shi, Xiao-meng; Wang, Zhi-xiang; Hu, Yan-li

Ma, Qin; Ruan, Ying-ying; Xu, Hui; Shi, Xiao-meng; Wang, Zhi-xiang; Hu, Yan-li.

Affiliation

Ma Q; Shihezi University, Shihezi, Xinjiang 832000, PR China; Yili Friendship Hospital, Yining, Xinjiang 835000, PR China.
Ruan YY; Shihezi University, Shihezi, Xinjiang 832000, PR China.
Xu H; Shihezi University, Shihezi, Xinjiang 832000, PR China.
Shi XM; Shihezi University, Shihezi, Xinjiang 832000, PR China.
Wang ZX; Graduate student office, Shihezi University, Shihezi, Xinjiang 832000, PR China.
Hu YL; Shihezi University, Shihezi, Xinjiang 832000, PR China. Electronic address: wzx330@163.com.

Biomed Pharmacother ; 76: 153-64, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26653563

Subject(s)

Alzheimer Disease/drug therapy; Chalcone/analogs & derivatives; Lipid Peroxidation/drug effects; Memory Disorders/prevention & control; Alzheimer Disease/physiopathology; Amyloid beta-Peptides/toxicity; Animals; Cerebral Cortex/drug effects; Cerebral Cortex/pathology; Chalcone/administration & dosage; Chalcone/pharmacology; Disease Models, Animal; Hippocampus/drug effects; Hippocampus/pathology; Male; Maze Learning/drug effects; Neurons/pathology; Peptide Fragments/toxicity; Phosphorylation/drug effects; Rats; Rats, Wistar; tau Proteins/metabolism

Key words

Alzheimer's disease; Kinase; Oxidative stress; Phosphatase; Safflower yellow; Tau hyperphosphorylation

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Lipid Peroxidation / Chalcone / Alzheimer Disease / Memory Disorders Language: En Journal: Biomed Pharmacother Year: 2015 Type: Article

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