Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study.
PLoS One
; 11(2): e0147894, 2016.
Article
in En
| MEDLINE
| ID: mdl-26881936
ABSTRACT
CONTEXT The relations between dietary and/or circulating levels of fatty acids and the development of type 2 diabetes is unclear. Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase activity delta-5 desaturase (D5D ratio) have been reported, as have adverse relations with saturated fatty acids and D6D ratio. OBJECTIVE:
To determine the associations between red blood cell (RBC) fatty acid distributions and incident type 2 diabetes.DESIGN:
Prospective observational cohort study nested in the Women's Health Initiative Memory Study.SETTING:
General population.SUBJECTS:
Postmenopausal women. MAIN OUTCOMEMEASURES:
Self-reported incident type 2 diabetes.RESULTS:
There were 703 new cases of type 2 diabetes over 11 years of follow up among 6379 postmenopausal women. In the fully adjusted models, baseline RBC D5D ratio was inversely associated with incident type 2 diabetes [Hazard Ratio (HR) 0.88, 95% confidence interval (CI) 0.81-0.95) per 1 SD increase. Similarly, baseline RBC D6D ratio and palmitic acid were directly associated with incident type 2 diabetes (HR 1.14, 95% CI 1.04-1.25; and HR 1.24, 95% CI 1.14-1.35, respectively). None of these relations were materially altered by excluding incident cases in the first two years of follow-up. There were no significant relations with eicosapentaenoic, docosahexaenoic or linoleic acids.CONCLUSIONS:
Whether altered fatty acid desaturase activities or palmitic acid levels are causally related to the development of type 2 diabetes cannot be determined from this study, but our findings suggest that proportions of certain fatty acids in RBC membranes are associated with risk for type 2 diabetes.
Full text:
1
Database:
MEDLINE
Main subject:
Fatty Acids, Omega-3
/
Linoleic Acid
/
Diabetes Mellitus, Type 2
/
Erythrocytes
/
Linoleoyl-CoA Desaturase
/
Fatty Acid Desaturases
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
America do norte
Language:
En
Journal:
PLoS One
Year:
2016
Type:
Article
Affiliation country:
United States