Complex Tissue and Disease Modeling using hiPSCs.
Cell Stem Cell
; 18(3): 309-21, 2016 Mar 03.
Article
in En
| MEDLINE
| ID: mdl-26942851
ABSTRACT
Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses will only be evident if all cellular and extracellular components of a tissue are present and functionally mature. To derive optimal benefit from such models, complex multicellular structures with vascular components that mimic tissue niches will thus likely be necessary. Here we consider emerging research creating human tissue mimics and provide some recommendations for moving the field forward.
Full text:
1
Database:
MEDLINE
Main subject:
Drug Evaluation, Preclinical
/
Induced Pluripotent Stem Cells
/
Models, Biological
Language:
En
Journal:
Cell Stem Cell
Year:
2016
Type:
Article
Affiliation country:
Netherlands